PRIME TEST

Clinical Study: Food intolerance - Military Polyclinic RM "Celio"

SCIENTIFIC STUDIES

• Randolph TG,Rawling FFA : Blood studies in allergy : V. Variations of total leukocytes following test feeding of foods ; an appraisal food test. Ann Allergy 1946; May-June 4 :16

• Pettay O: Preliminary report on the use of a in vitro leukocytolysis as a test in allergy. (Abstract) Scandinavian J Clinical Laboratory Investigation 1952; 4:77.

• Waksman BH : Specific white cell lysis produced by combination of rabbit antiserum to purified protein (ovalbumin, bovine gamma globulin) with homologous antigen : the role of the non-precipitating antibody. Immunology 1953; 70:331-334.

• Hartman JD, Hock WC: Changes in blood leucocytes resulting from antigen antibody reactions. American J Psycology 1955; 183: 214-220

• Black AP: A new diagnostic method of allergic disease. Pedriatics 1956; 17:716-724.
  
• Bryan WTK, Bryan MP: The application of in vitro cytotoxic reactions to clinical diagnosis of food allergy. Laryngoscope 1960 ; 70:810-824.
  
• Speirs RS: The action of antigen upon hypersensitivity cells. Ann New York Academy Science 1964; 113:819-824
  
• Ruddle NH,Waksman BH: Cytotoxicity mediated by soluble antigen and lymphocytes in delayed hypersensitivity. J Exp Medicine Dec !968; 128
  
• Bryan WTK,Bryan MP : Cytotoxic reactions and the diagnosis of food allergy.Laryngoscope 1969;79: 1453-1472
  
• Bryan WTK,Bryan MP : Cytotoxic reactions and the diagnosis of food allergy Otolaryngologic Clinics of North America 1971; 4:523-534
  
• Bryan WTK, Bryan MP: Clinical examples of resolution and some idiopathic and other chronic diseases by careful allergic management. Laryngoscope 1972; 82:1231-1238
  
• Ulett GA, Perry SG: Cytotoxic food testing and leukocyte increase as an index to food sensitivity Ann Allergy 1974; 33:23-32.
  
• Ulett GA, Perry SG: Cytotoxic testing and leukocyte increase as an index to food sensitivity. II.Coffee and tobacco. Ann Allergy 1975; 34:150-160
  
• Hughes EC: Chemically defined diet in the diagnosis and management of allergy or food intolerance. I. With a group of sensorineural hearing impaired. Trans AM Acad Ophtalmol and Otolaryngol Allergy 1975; 15:60-71.
  
• Bryan WTK,Bryan MP: Diagnosis of food allergy by cytotoxic reactions. Trans Am Sc Ophthalmol and Otolaryngol Allergy 1976;15:14-23.
  
• Brickmore JT: Leukocyte test for food allergies: its application toward clinical practice. Trans Am Soc Ophthalmol Otolaryngol Allergy 1976; 16:101-108.
  
• UpdegraffTR: Food allergy and cytotoxic tests. Ear Nose Throat J 1977; 56:450-459. Also Trans Am Soc Ophthalmol and Otolaryngol Allergy 1977; 16:48-64.
  
• Hghes EC: chemically defined diet in the diagnosis of food sensitivity. II. With a panel of seriously sensitive patients. Trans Am Soc Ophthamol Otolaryngol Allergy 1977; 17:43-65.
  
• Boyles JH. The validity of using the cytotoxic food test in clinical allergy. Ear Nose throat J 1977; 56:35-43.
  
• Oeling A, Martin-Gil D,JerezJ,Subira ML; In vitro diagnosis of food allergy. Allergol Immunopathol (Madr.) 1978;6:153-161
  
• Rubin JL ,GriffithsRW,HillHR:Allergen-induced depressionof neutrophil chemotaxis in allergic individuals. J Allergy Clin Immunol 1978; 62:301-308.
  
• Hughes EC Use of a chemically defined diet in the diagnosis of food sensitivity and the determination of offending foods. Ann Allergy 1978; 40:393-398.
  
• Hughes EC,Gottschalk GH: Comparison of cytotoxic test for food sensitivities with food challenge experience : effect of sample timing. Trans Am Acad Ophtalmol Otolaryngol Allergy 1978; 40:393-398.
  
• Hughes EC Oettinger L, Johnson F,Gottschalk GH: Case report: A chemically defined diet in diagnosis and management of food sensitivity in minimal brain dysfunction Ann Allergy 1979;42:174-176
  
• Ulett GA : Food allergy: Cytotoxic testing and the central nervous system. Psychiatric J Univ. Ottawa 1980; 5:100-108
  
• Stavish GE: The clinical aspects of the cytotoxic test The Bion 1980
  
• Holopainen E, Palva T, Stenberg P, Backman A, Legti H, Ruokonen J: Cytotoxic leukocyte reaction. Acta Otolaryngol 1980;222-226.
  
• Ruokonen J, Holopainen E, Palva T, Backman A: Secretory otisis media and allergy with special reference to the cytotoxic leucocyte test. Allergy 1981; 36:59-68.
  
• Ruokonen J: Reactions in the cytotoxic leucocyte test. Allergol Immunopathol (Madr.) 1981; 9:281-288
  
• Hopkins JM, Tomlinson VS, Jenkins RM: Variation in response to cytotoxicity of cigarette smoke. Br Med J 1981; 283:1209-1211.
  
• West WG : Food sensitivities through the cytotoxic test. The Bion 1981.
  
• Stavish GE: Clinical application of cytotoxic test as it realtes to comprehensive ecological investigation. The Bion 1981.
  
• Stromp MA : The beauty of the cytotoxic test. Preventive Medicine Forum Fall 1981.
  
• Bienviste J: The human basophil degranulation test as an vitro method for diagnosis of allergies. Clinical Allergy 1981; 11:1-11.
  
• Trevino RJ Immunologic mechanism in the production of food sensitivities. Laryngoscope 1891; 91:1913-1936
  
• Hughes EC, Gottschalk GH Kaufmann D : Effect of time of blood sampling on in vitro tests food sensitivities. Ear Nose Throat J 1982; 61:81-87.
  
• Ruokonen J,Paganus A, Lehti H: Elimination diets in the treatment of secretory otitis media. Int J Pediatr Otorhinnolaryngol 1982, 4:39-46
  
• King I : The cytotoxic test, uncovering hidden food allergies. Inter J Holistic Health & Medicine 1983; 2:30-32.
  
• Palva T, Legtinen T, Malmberg H: Separation of granulocytes for the cytotoxic leucocyte test. Laryngoscope 1983; 93:242-244.
  
• Podleski WK: Cytodestructive mechanisms provoked by food antigens. II Antibody-dependent allergic autocytotoxicity. Allergy 1985; 40:166-172.
  
• Cheraskin E, Allen J Zavik J : The psycotherapic implications of cytotoxic testing. J Orthomolecular Psychiatry 1985 ; 14:128-135.
  
• Opodleski WK: Cydestructive mechanisms provoked by antigens. I. Direct,allergic autocytotoxicity . Allergy 1985; 40:157-165
  
• Podleski WK: Spontaneous allergic autocytotoxicity in bronchial asthma associated with food allergy. American J Medicine 1986; 81:437-442.
  
• Pasula MJ: A Possible new whole blood assay for delayed hypersensitivity reaction. AMT CE Supp July 1988; 178-179.
  
• Fell PJ, Brostoff J Pasula MJ: High correlation of the ALCAT test results with double-blind challenge (DBC) in food sensitivity. Ann Allergy 1989; 62:253.
  
• Sandberg DH, Pasula MJ: A comparison of the ALCAT test for food reactions amongst 2 population sub-groups. Ann Allergy 1989; 62:271.
  
• Pasula MJ: The ALCAT test : in vitro procedure for determining food sensitivity . Folia Medical Cravoviensia 1993; 34 (1-4): 153-157.
  
• Sinkovics J,Horvath J: Cytotoxic human lymphocytes: from in vitro testing (1970s) to immunotherapy (1990s). Acta Microbiologica Hungarica 1993; 40(3):165-179.
  
• Goguen B, Kedersha N: Clonogenic cytotoxicity testing by microdrop encapsulation. Nature May 1993; 263(6425): 189-190.
  
• Lam KM: A Cytotoxicity test for the detection of Campylobacter jejuni toxin. Veterinary Microbiology May 1993; 35(1-2):133-139.
  
• Wang XM, Terasaki PI, Rankin GW Jr, Chia D, Zhong HP, Hardy S: A new microcellular cytotoxicity test based on calcein AM release. Human Immunology Aug 1993; 37(4): 264-270.
  
• Hoj L. Food intolerance in patients with angioedema and chronic urticaria: An investigation by RAST and ALCAT test. European J of Allergy and Clinical Immunology 1995; 26(50).
  
• Hoj L: Diagnostic value of ALCAT test in intolerance to food additives compared with double-blind placebo-controlled (DBPC) oral challenges. J Allergy and Clinical Immunology 1996; )/ (1) 3.
  
• Kaats GR, Pullin D, Parker LK: The short term efficacy of the ALCAT test of food sensitivities to facilitate changes in body composition and self reported disease symptoms: A Randomized controlled study. Amer J Bariatric Medicine Spring 1996; 18-23.